Mysimba anti-obesity medication

MySimba ContraveMysimba is an anti-obesity medication developed in the America by Orexigen Therapeutics. It contains the drugs Bupropion and Naltrexone and is marketed in the States under the Contrave brand name.

Like Phentermine, Belviq and Orlistat, Mysimba is only available with a prescription and is only offered to people who have achieved an unusually high level of obesity, so many dieters will find it is not an option that will be available to them.

As with the other medications doctors are permitted to prescribe, Mysimba is known to have the potential to cause a wide range of side effects.

In fact, the chance of side effects is so high that, when the European Commission granted the drug marketing authorisation, in 2015, the European health watchdog, Prescrire, stated its use was “too risky” for the modest amount of weight loss it provides.

PhenQ by Bauer NutritionWe recommend products such as PhenQ over MySimba. It is our opinion that PhenQ offers a better and safer success rate.

PhenQ is a multi action diet pill that can help you to lose weight by burning existing fat, blocking the potential for new fat and suppressing appetite. PhenQ has a very good returns policy of 60 days.

Read why PhenQ is so popular by clicking here

What is Mysimba?

how to control hungerMysimba is an appetite suppressant that can lessen hunger urges and help dieters to stick to a diet that is sufficiently low in calories to encourage the body to burn its stores of fat.

The drug combination it provides stimulates the hypothalmus. This is the area of the brain that regulates the appetite and controls energy expenditure. The medication also affects the region of the brain that process the reward aspects of eating and food related stimuli.

Mysimba Ingredients

Each Mysimba diet pill contains:

  • Bupropion (78mg): A drug that is that is primarily used as an antidepressant and can also be good for killing the nicotine cravings experienced by people who are trying to stop smoking. You can learn more about Buproprion here.
  • Naltrexone (90mg): This drug is generally prescribed to people who are trying to wean themselves of opioid drugs, like heroin, and to people trying to overcome their alcohol dependence. You can learn more about Naltrexone here.

MySimba Potential

MySimba ContraveOrexigen Therapeutics decided to combine the two drugs used in Mysimba after it was noticed Bupropion users often lost weight.

It is believed that this could be due to the drug’s ability to boost dopamine levels, but this speculation has never been proved. The thing that lets the drug down, as far as weight loss goes, is the appetite suppressing effect diminishes as people become accustomed to using it.

Orexigen Therapeutics believed Naltrexone may have the ability to allow Buproprion to work as a longer term appetite suppressant and research suggests this is true. However, the degree of weight loss provided is not particularly impressive.

The data collected from one clinical trial showed 50.8% of the volunteers had achieved a 5% body weight reduction by the 16th week. This is not particularly impressive and it has to be remembered nearly 50% of the volunteers failed to achieve even this degree of weight loss.

Recommended Dosage and Usage Considerations

Mysimba must be used in association with diet and exercise. The pills have to be taken with water and should be swallowed whole because people who chew them or allow them to dissolve in the mouth are more likely to experience side effects. New users begin by taking one pill per day. The dose is then upped over the subsequent weeks.

  • Week 1: 1 pill each morning
  • Week 2: 1 pill in the morning + 1 pill in the evening
  • Week 3: 2 pills in the morning + 1 pill in the evening
  • Week 4: 2 pills in the morning + 2 pills in the evening

Usage Restrictions and Potential Side Effects

Mysimba diet pills are unsuitable for pregnant and nursing a mothers. Mysimba can also interact badly with certain other drugs and medications. Its use may also aggravate some medical conditions.

Some of the potential side effects users may experience include:

  • Anxiety
  • Headaches
  • Insomnia
  • Restlessness
  • Difficulty concentrating
  • Racing heart
  • Dizzies
  • Hot flushes
  • Nausea
  • Changes to the bowel movement
  • Muscular aches and pains
  • Liver damage
  • Manic episodes
  • Thoughts of suicide

Feedback From Mysimba Users

“I’ve definitely lost weight with Mysimba, but it’s only worked out to be a couple of pounds a week. I have friends that have done better than that with pills they’ve bought at the supermarket and they never experienced any side effects. I’ve been getting bad headaches right from the start. It’s been a month and there is still no sign of them letting up.”

“I lost 6lbs in the first 14 days, but had to stop taking this medication because it made me feel too sick and dizzy to function at work.” 

“Never again. I got severely constipated while I was using Mysimba, got lots of bad heads, and felt pretty dizzy a lot of the time. One week of that was all I could take.” 

“My doctor said there could be some side effects, but I must be one of the lucky ones because I’ve had no problems at all. I’ve been taking the pills for 2 months and have lost around 14lbs.”

Our Summary of Mysimba

We’re inclined to agree with the watchdogs at Prescrire, Mysimba does not appear to be strong enough to provide a degree of weight loss that makes the associated health risks worthwhile.

Even some of the poorer quality over-the-counter diet pill options can offer better benefits, and the top diet pill brands, like PhenQ, can do so without causing side effects. Such pills are also more suitable for long-term use and can be purchased and used by anyone who wishes to need weight, not just those who are extremely obese.

Click here to view the best diet pills available without a prescription

Phentermine, How Does it Work, Can I Buy Phentermine over the Counter without Prescription

Phentermine CapsulesPhentermine has been one of the most prescribed diet pills on a worldwide basis since its inception and introduction in the late 1950″s. It has had a fairly chequered history but remains in demand due largely to its reputation as one of the strongest diet pills ever produced.

Phentermine is classed a controlled substance, or drug for want of a better word. You cannot buy Phentermine either online or over the counter – this fact has to stressed as there are dozens of websites claiming to sell genuine Phentermine. These websites are either supplying a replica or worse still counterfeit product.

There is however a legitimate market for Phentermine alternatives with a handful of brands forging a niche market for themselves offering arguably a better, faster, safer weight loss solution than the real thing.

What Is Phentermine

diet drugAs touched upon above, it is a drug classed medication that was manufactured initially in 1959 with the purpose of treating obesity by capsule based medication. It is a conjugation of phenyl-tertiary-butylamine and has been used either on its own in combination with other diet drugs over the last half a century.

It is available via prescription only in many countries including the United States, Canada, Great Britain, Ireland and Australia.

Phentermine is the generic substance – it is also known under the following brand names:

  • Adipex-P, Suprenza, Ionamin
  • Duromine, Obephen, Obermine
  • Obestin-30, Redusa, Panbesy

How Does Phentermine Work

suppress appetite with PhentermineIt is an appetite suppressant that can help patients that are morbidly obese reduce their calorific intake by reducing their cravings for food.

The drug works by affecting or stimulating hypothalamus (the part of the brain that among other things is responsible for controlling hunger) – when this part of brain is stimulated sufficiently it releases a signal to the body that it is full and does require sustenance.

There is also a secondary mechanic of action – additional hormones such as epinephrine or adrenaline are released independently that trigger the breakdown of stored fat cells.

The appetite suppressing effect only occurs until a certain point until the body becomes accustomed to it and builds a tolerance. For this reason it is advised to only use for a short period of time.

Phentermine has also been combined with other diet drugs over the course of its existence to form a another compound. Some common by products are:

Combined with Fenfluramine to form an appetite suppressant and fat burning under the name Fen-Phen.

Combined with Dexfenfluramine to form the product Dexfen-Phen

Phentermine Side Effects

The biggest drawback to its usage has and always has been its association with side effects. Below is a description of just some of the side effects that have been reported, noted and disclosed.

Some of more serious side effects include: chest pain, anxiety, heart palpitations, raised blood pressure, jittery feeling, dizziness, shaking, insomnia, breathing difficulties, dizziness and swelling of the legs and ankles.

Some less serious include: metallic taste in mouth, diarrhoea, constipation and sickness

How To Obtain Phentermine

As described above the only legal way to acquire is to make an appointment with your doctor to ascertain your eligibility. If you are a suitable candidate you may be given a prescription.

Avoid purchasing from the internet no matter how tempting.

Alternatives To Phentermine

There are several commercial diet pills that are suitable alternatives and available to buy without prescription.

Some of the later introduction are arguably more effective and certainly a lot safer. Phentermine it has to remembered was introduced over 50 years ago and has remained virtually unchanged ever since.

What is PhenQOur recommendation is for PhenQ. It is both and appetite suppressant and fat burner and has been formulated under conditions that have been registered by the FDA – there are not many commercial product that can lay claim to this.

The sheer number of positive testimonials attached to PhenQ is it real selling point. The owners actively encourage its users to send in before and after photo’s, commentary of progress even video’s. If you considering the Phentermine experience consider PhenQ.

Click here to read the full review

Further Reading and Resources

http://en.wikipedia.org/wiki/Phentermine

http://www.nlm.nih.gov/medlineplus/druginfo/meds/a682187.html