Mysimba anti-obesity medication

MySimba ContraveMysimba is an anti-obesity medication developed in the America by Orexigen Therapeutics. It contains the drugs Bupropion and Naltrexone and is marketed in the States under the Contrave brand name.

Like Phentermine, Belviq and Orlistat, Mysimba is only available with a prescription and is only offered to people who have achieved an unusually high level of obesity, so many dieters will find it is not an option that will be available to them.

As with the other medications doctors are permitted to prescribe, Mysimba is known to have the potential to cause a wide range of side effects.

In fact, the chance of side effects is so high that, when the European Commission granted the drug marketing authorisation, in 2015, the European health watchdog, Prescrire, stated its use was “too risky” for the modest amount of weight loss it provides.

PhenQ by Bauer NutritionWe recommend products such as PhenQ over MySimba. It is our opinion that PhenQ offers a better and safer success rate.

PhenQ is a multi action diet pill that can help you to lose weight by burning existing fat, blocking the potential for new fat and suppressing appetite. PhenQ has a very good returns policy of 60 days.

Read why PhenQ is so popular by clicking here

What is Mysimba?

how to control hungerMysimba is an appetite suppressant that can lessen hunger urges and help dieters to stick to a diet that is sufficiently low in calories to encourage the body to burn its stores of fat.

The drug combination it provides stimulates the hypothalmus. This is the area of the brain that regulates the appetite and controls energy expenditure. The medication also affects the region of the brain that process the reward aspects of eating and food related stimuli.

Mysimba Ingredients

Each Mysimba diet pill contains:

  • Bupropion (78mg): A drug that is that is primarily used as an antidepressant and can also be good for killing the nicotine cravings experienced by people who are trying to stop smoking. You can learn more about Buproprion here.
  • Naltrexone (90mg): This drug is generally prescribed to people who are trying to wean themselves of opioid drugs, like heroin, and to people trying to overcome their alcohol dependence. You can learn more about Naltrexone here.

MySimba Potential

MySimba ContraveOrexigen Therapeutics decided to combine the two drugs used in Mysimba after it was noticed Bupropion users often lost weight.

It is believed that this could be due to the drug’s ability to boost dopamine levels, but this speculation has never been proved. The thing that lets the drug down, as far as weight loss goes, is the appetite suppressing effect diminishes as people become accustomed to using it.

Orexigen Therapeutics believed Naltrexone may have the ability to allow Buproprion to work as a longer term appetite suppressant and research suggests this is true. However, the degree of weight loss provided is not particularly impressive.

The data collected from one clinical trial showed 50.8% of the volunteers had achieved a 5% body weight reduction by the 16th week. This is not particularly impressive and it has to be remembered nearly 50% of the volunteers failed to achieve even this degree of weight loss.

Recommended Dosage and Usage Considerations

Mysimba must be used in association with diet and exercise. The pills have to be taken with water and should be swallowed whole because people who chew them or allow them to dissolve in the mouth are more likely to experience side effects. New users begin by taking one pill per day. The dose is then upped over the subsequent weeks.

  • Week 1: 1 pill each morning
  • Week 2: 1 pill in the morning + 1 pill in the evening
  • Week 3: 2 pills in the morning + 1 pill in the evening
  • Week 4: 2 pills in the morning + 2 pills in the evening

Usage Restrictions and Potential Side Effects

Mysimba diet pills are unsuitable for pregnant and nursing a mothers. Mysimba can also interact badly with certain other drugs and medications. Its use may also aggravate some medical conditions.

Some of the potential side effects users may experience include:

  • Anxiety
  • Headaches
  • Insomnia
  • Restlessness
  • Difficulty concentrating
  • Racing heart
  • Dizzies
  • Hot flushes
  • Nausea
  • Changes to the bowel movement
  • Muscular aches and pains
  • Liver damage
  • Manic episodes
  • Thoughts of suicide

Feedback From Mysimba Users

“I’ve definitely lost weight with Mysimba, but it’s only worked out to be a couple of pounds a week. I have friends that have done better than that with pills they’ve bought at the supermarket and they never experienced any side effects. I’ve been getting bad headaches right from the start. It’s been a month and there is still no sign of them letting up.”

“I lost 6lbs in the first 14 days, but had to stop taking this medication because it made me feel too sick and dizzy to function at work.” 

“Never again. I got severely constipated while I was using Mysimba, got lots of bad heads, and felt pretty dizzy a lot of the time. One week of that was all I could take.” 

“My doctor said there could be some side effects, but I must be one of the lucky ones because I’ve had no problems at all. I’ve been taking the pills for 2 months and have lost around 14lbs.”

Our Summary of Mysimba

We’re inclined to agree with the watchdogs at Prescrire, Mysimba does not appear to be strong enough to provide a degree of weight loss that makes the associated health risks worthwhile.

Even some of the poorer quality over-the-counter diet pill options can offer better benefits, and the top diet pill brands, like PhenQ, can do so without causing side effects. Such pills are also more suitable for long-term use and can be purchased and used by anyone who wishes to need weight, not just those who are extremely obese.

Click here to view the best diet pills available without a prescription

Thiomucase Quemagrasas Celulítico UK

<div class="snvdshc"><div class="synved-box-message synved-box-plain"></div></div>Thiomucase Quemagrasas Celulítico is a supplement produced by Almirall pharmaceutical company. The company markets medicines and other pharmaceutical products to customers all over the world and is responsible for creating the anti-migraine drug Almotriptan, which holds the distinction of being the first Spanish R&D medicine to be approved by the American FDA.

Thiomucase Quemagrasas Celulítico is a product that is primarily designed as a treatment for cellulite and may also help accelerate weight loss. It’s alleged to be capable of ridding the skin of cellulite in as little as 28 days, but customer reviews suggest it may not be up to the task.

Claims :Thiomucase Quemagrasas Celulítico is a product that is primarily designed as a treatment for cellulite

Pros: Respected company with a long history

Cons : Customer reviews are a mixture of positive and negative

Click here to find out which diet products are most popular

Thiomucase Quemagrasas Celulítico Ingredients

None of the sites marketing the product provide a full ingredient profile, but the active ingredients appear to be:

  • Bitter Orange: A citrus fruit extract that provides a fat burning chemical called synephrine. The ingredient is not normally associated with cellulite removal, but it’s a key fat burning ingredient in many supplements that are intended to help make it easier for people to lose weight. Synephrine’s weight loss enhancing ability has been studied on numerous occasions by research teams all over the world and although some studies suggest it works other indicate otherwise. However, researchers at Creighton University Medical Center, in Omaha, USA, evaluated the results of a number of human studies involving bitter orange and concluded: “Modest increases in weight loss were observed with bitter orange extract/p-synephrine-containing products when given for six to 12 weeks.”
  • Chromium: Although it’s unlikely to have a direct effect on cellulite, chromium is a very popular diet pill ingredient that has the ability to prevent the sugar spikes that can sometimes occur after a meal has been eaten and may trigger a desire for sweet and sugary food.
  • Zinc: A versatile mineral that is often added to testosterone boosting supplements and is also included in many diet pill formulations. It’s unclear if there is a relationship between zinc and cellulite, but people who are zinc deficient are more likely to experience inhibited collagen production. This can be bad news because adequate collagen levels are necessary for healthy-looking skin.
  • Cola de Caballo: An ingredient that is often added to creams and ointments that are intended to reduce cellulite. Cola de Caballo shows a lot of promise when it is used in this way, but ingesting it by mouth is unlikely to produce a similar effect.
  • Chitoglucán: A patented ingredient that contains extracts taken from a species of edible fungus. It’s intended to work as a fat blocker. Ingredients of this nature absorb food-provided fats within the stomach and prevent them from being digested. Chitoglucán has a lot of potential as a weight loss aid, but the manufacturer’s website makes no claims about the ingredient’s potential as an anti-cellulite treatment.
Usage Instructions – Two pills are required per day. The first one should be taken before lunch. The second before eating the evening meal.

Thiomucase Quemagrasas Celulítico Customer Feedback

Customer feedback is mixed.

A few average customer reviews read:

“The cellulite around my upper arms is disappearing thanks to these pills and is no longer sapping my confidence or making me feel so self-conscious I have to wear long sleeves all the time.”

“I wanted to get rid of the cellulite on my thighs. I thought this product would help but it didn’t do a thing.”

“I lost 6 pounds by using this product with diet and exercise, so it appears to work okay.” 

“I tried it for a month, but I never lost any weight and my cellulite is still as hideous as it ever was.”

Side Effects of Thiomucase Quemagrasas Celulítico

No side effects have been reported, but Thiomucase Quemagrasas Celulítico will be unsuitable for pregnant or nursing mothers. People with existing health issues should always seek medical advice before using any brand of supplement for the first time. The same advice is offered to people who are using medication.

Where to Buy Thiomucase Quemagrasas Celulítico

Thiomucase Quemagrasas Celulítico is available via many online stores, including Farmacia en Casa and PromoFarma. There are 60 capsules per pack and the price is usually 26 € to 34 €.


There is no money back guarantee.

The Bottom Line

Looking at the formulation of ingredients used in the product, Thiomucase Quemagrasas Celulítico probably offers the most value as a weight management product.

Cellulite is caused when fat deposits form underneath the skin, so it is possible that use of the formulation may also reduce that distinctive marbling of the skin that is caused by this kind of fat build up.

However, the same could be said for any brand of diet pill and Thiomucase Quemagrasas Celulítico does not compare well to the leading products of the day. The best of them come with a 60-day money back guarantee. Thiomucase Quemagrasas Celulítico has no guarantee at all, so it’s pretty safe to say there are better options available.

Which weight loss products are most effective – click here

GlucoMetasyn Review – Prevent Metabolic Syndrome

GlucoMetasyn Review - Prevent Metabolic SyndromeGlucoMetasyn is a food supplement produced in France by OTC Trade.

The company’s track record as a supplement manufacturer is exemplary and they produce  another product (a fat blocker called LipoMetasyn).

OTC Trade products are manufactured in factories that conform with strict European standards and they only use non-GMO ingredients taken from plants that have been farmed using organic farming methods.

Although this does not guarantee an effective product, the quality of the ingredients used in both the company’s products is likely to be unusually good because they are obtained by supercritical fluid extraction. This method is known to be extremely effective and provides an extract that is more pure and potent than extracts obtained using normal extraction techniques.

Claims : To Helps prevent metabolic syndrome, improves carbohydrate metabolism and control blood sugar levels

Pros: Respected company with a long history

Cons : Only available to customers in French speaking countries. Other weight loss products are preferred

Click here to find out which diet products are most popular

Promised Benefits and Key Selling Points

  • Kosher and Halal certified
  • Helps prevent metabolic syndrome
  • Improves carbohydrate metabolism
  • Controls blood sugar levels
  • Lowers cholesterol
  • Assists weight loss

The OTC Trade website contains a page full of information about metabolic syndrome. This suggests the product is probably primarily intended for people who are suffering from the disorder.

People with metabolic syndrome often have a range of symptoms, which can include excess fat around the waist, elevated blood pressure, and high cholesterol levels.

GlucoMetasyn LipoMetasyn

If GlucoMetasyn is capable of doing the things the marketing material says it will, it could have the potential to save lives because people who have metabolic syndrome are more susceptible to heart attacks.

However, although the pills may offer benefits that could influence the body weight for the better, they cannot and should not be seen as being a diet pill. They are incapable of suppressing the appetite or directly influencing fat burning ability, and are unlikely to give dieters the kind of support they need.

Key Ingredients and Blend Potential

Each GlucoMetasyn capsule contains:

  • FenugreekFénugrec (500mg): Although many people see fenugreek as nothing more than a cooking spice, it’s believed to possess many medicinal qualities and is alleged to promote a healthy heart. According to one reliable source, fenugreek may be capable of lowering blood sugar levels, raising “good” cholesterol levels, and helping keep “bad” cholesterol levels under control. The ingredient can also improve the appetite though. This could make GlucoMetasyn a poor choice for anyone who is trying to lose weight and already has difficulty in saying “no” to food.
  • Nigella (600mg): Sometimes called “black seed”, nigelle sativa has been valued as a medicine for more than 2000 years and traditional uses include the treatment of toothache, asthma, and hemorrhoids. It is also believed to be capable of lowering elevated blood pressure and cholesterol levels, but further study is required all around.
How to Use – capsules should be taken with water and only one (2 capsule) dose is required per day, just before going to bed.

GlucoMetasyn Side Effects

If OTC Trade are aware of any side effects they fail to mention it in their marketing material, but nigella is an anticoagulant, so GlucoMetasyn is unlikely to be suitable for people suffering from bleeding disorders or for anyone who is about to undergo surgery.

It also modulates blood sugar levels. This may make the product a poor option for anyone who is diabetic. GlucoMetasyn will not be a suitable option for pregnant or nursing mothers. Anyone who has existing health problems will need to ask a doctor’s advice before using this supplement. People who are using medication will need to be equally cautious.

Where to Buy GlucoMetasyn

You can buy GlucoMetasyn from the OTC Trade website at a cost of 31,95 € per box (contains 36 capsules). Customers who add an extra box or two to their order, or buy one box of GlucoMetasyn and a box of LipoMetasyn, receive a small discount.


GlucoMetasyn is not backed by a money back guarantee as far as we can ascertain

The Verdict

If you are looking for a good diet pill, GlucoMetasyn is poor choice. At best, weight loss is only likely to be a secondary effect but it is conceivable that the formulation may offer limited value to people who are already losing weight by using a combination of diet and exercise.

There is also a chance the appetite boosting abilities of fenugreek may make it harder for GlucoMetasyn users to stick to a calorie controlled diet.

Looking at the abilities of the two ingredients used in the formulation, GlucoMetasyn is likely to be a better option for people who have high cholesterol levels, but we fail to see why the product would be particularly good for people with metabolic syndrome, and anybody suffering from the disorder would probably only be aware of it if their doctor had diagnosed it.

In a situation such as that the doctor would also be likely to prescribe/recommend the correct treatment and make suggestions for any lifestyle changes that may be required.

View our list of most effective diet pills here